Chiasma is focused on improving the lives of patients who face challenges associated with their existing treatments for rare and serious chronic diseases. Employing its Transient Permeability Enhancer (TPE®) technology platform, Chiasma seeks to develop oral medications that are currently available only as injections. In July 2019, the Company reported positive top-line data from its completed Phase 3 clinical trial of its octreotide capsules product candidate, conditionally trade named MYCAPSSA, for the maintenance therapy of adult patients with acromegaly. In January 2020, the FDA accepted for review the resubmission of Chiasma’s New Drug Application seeking marketing approval for MYCAPSSA in the United States and assigned PDUFA action date of June 26, 2020. The Company is also currently conducting a Phase 3 multinational clinical study designed for EMA commercial approval.  Chiasma is headquartered in Needham, MA with a wholly owned Israeli subsidiary. 

The MSL (Director) -Rare Disease is a field-based position and will serve as a scientific peer and resource within the rare disease medical community, and act as a scientific expert to his/her colleagues. He/she is responsible for developing and enhancing professional relationships with medical thought leaders and key opinion leaders (KOL’s) in the rare disease space. This position reports to the Vice President Medical Affairs.


  • Provide field insights and activity update through regular meetings and other communication channels with the Vice President, Medical Affairs

  • Provide medical information and facilitate scientific exchange in a fair and balanced manner and provide clinical insight and support for Chiasma

  • Provide disease education as appropriate. Implement clinical and educational strategies in collaboration with colleagues

  • Provide clinical presentations and information in response to unsolicited questions (as appropriate) in academic, community, and healthcare provider settings in both group and one-one settings

  • Establish, build and maintain relationships with Key Opinion Leaders (KOLs) and other healthcare professionals in endocrinology, neurosurgery and other applicable rare disease specialties

  • Ensure appropriate dissemination of clinical and scientific information in a timely, ethical and customer-focused manner

  • Gain feedback through field interactions with HCPs to uncover collaboration opportunities and pair customer’s unmet needs with available internal resources

  • In partnership with clinical operations, support trial awareness, enrollment, and identification of potential sites/investigators for clinical trial participation

  • Contribute to the overall strategic focus of the Medical Affairs team

  • Collaborate across multiple functions and within a region(s) to maximize territory opportunities

  • Support clinical trials as needed as well as investigator-initiated trials

  • Participate in the identification and publication of scientific materials

  • Align customers educational and research needs with available Chiasma resources and will provide the latest emerging data in response to specific healthcare professional inquiries


  • MSN, PharmD or PhD required

  • 5-10 years’ experience MSL field- based experience in the pharmaceutical/biotech industry is required

  • Some experience in a Rare Disease MSL role providing strategic and scientific/medical direction is preferred

  • Thorough knowledge of medicine, treatment guidelines, clinical research processes, customer strategies, and FDA promotional guidelines, regulations, and ethical guidelines applied to the pharmaceutical industry is essential

  • Must be scientific oriented and be able to prioritize and work effectively in a constantly changing environment

  • Outstanding business acumen

  • Excellent interpersonal, communication, and presentation skills required

  • Ability to network and partner with important customers, including thought leaders large group practices, medical directors and pharmacy directors is required

  • Working knowledge of Microsoft Office Suite (Word, Power Point and Excel) and associated hardware is required

  • Ability to travel overnight is required

Chiasma Inc. (the "Company") is an equal opportunity employer.  All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law.  Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities.  If you require an accommodation in the application process, please contact a member of the Company’s Human Resources department.